Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | SMO | Q99835 | 5/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ERG | P11308 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116751 | 0.90 | LMNA (0.53) | HSD11B1HTTALDH1A1TSHRLMNA | |
| SCHEMBL20117293 | 0.86 | HSD11B1 (0.45) | HSD11B1SMN1; SMN2SMO | |
| SCHEMBL20676529 | 0.83 | SMO (0.39) | HTTTSHRDGAT1LMNASMO | |
| SCHEMBL20116823 | 0.83 | SMN1; SMN2 (0.46) | HTTALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL20116843 | 0.82 | LMNA (0.46) | HTTTSHRLMNASMN1; SMN2NPSR1 | |
| SCHEMBL20116723 | 0.81 | LMNA (0.42) | TSHRLMNASMOTUBB4ATUBB | |
| SCHEMBL20676430 | 0.80 | LMNA (0.41) | HTTTSHRLMNASMN1; SMN2SMO | |
| SCHEMBL20116742 | 0.78 | HSD11B1 (0.54) | HSD11B1HTTALDH1A1TSHRLMNA | |
| SCHEMBL20116753 | 0.78 | GRM5 (0.54) | HSD11B1HTTALDH1A1TSHRLMNA | |
| SCHEMBL20117211 | 0.77 | KIT (0.36) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |