Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20676512 | 0.91 | SMN1; SMN2 (0.42) | HSD11B1SMN1; SMN2UBE2MDCUN1D1MGLL | |
| SCHEMBL20116841 | 0.89 | MGLL (0.47) | HSD11B1SMN1; SMN2MGLLKITSMO | |
| SCHEMBL20116745 | 0.86 | HSD11B1 (0.51) | HSD11B1SMN1; SMN2SMO | |
| SCHEMBL20116228 | 0.77 | HSD11B1 (0.47) | HSD11B1SMN1; SMN2TP53UBE2MDCUN1D1 | |
| SCHEMBL20116775 | 0.76 | SMN1; SMN2 (0.41) | HSD11B1SMN1; SMN2KIT | |
| SCHEMBL20116751 | 0.75 | LMNA (0.53) | HSD11B1SMN1; SMN2MGLLEPHX2SMO | |
| SCHEMBL20676598 | 0.74 | SMN1; SMN2 (0.43) | HSD11B1SMN1; SMN2UBE2MDCUN1D1EPHX2 | |
| SCHEMBL20116785 | 0.73 | KIT (0.42) | SMN1; SMN2MGLLKITEPHX2SMO | |
| SCHEMBL22358562 | 0.71 | HSD11B1 (0.49) | HSD11B1SMN1; SMN2TP53UBE2MDCUN1D1 | |
| SCHEMBL20676489 | 0.69 | TBK1 (0.48) | SMN1; SMN2KITRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |