Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 2/20 | 0.37 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22357755 | 0.85 | MTNR1A (0.37) | MTNR1AMTNR1BNPC1MAPTKDM4E | |
| SCHEMBL20116946 | 0.78 | MPO (0.37) | MAPTKDM4EHSD17B10MAPK8NLRP3 | |
| SCHEMBL20117055 | 0.78 | HTR6 (0.34) | NLRP3 | |
| SCHEMBL20117058 | 0.78 | HTR2A (0.37) | MAPTKDM4EHSD17B10MAPK8NLRP3 | |
| SCHEMBL20117051 | 0.77 | SYK (0.36) | NPC1MAPTKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL14817010 | 0.71 | KDM4E (0.42) | KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL27051631 | 0.70 | NR1I2 (0.38) | NPC1MAPTKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL20116565 | 0.69 | GRM4 (0.44) | MAPTKDM4EHSD17B10SMN1; SMN2LMNA | |
| SCHEMBL20749527 | 0.68 | HTR4 (0.36) | NPC1MAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3604215 | 0.68 | SLC22A12 (0.44) | MAPTNLRP3ALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |