Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886283 | 0.88 | — | — | |
| SCHEMBL1205890 | 0.86 | KDM4E (0.34) | KDM4EALDH1A1NOTUMIDO1NPC1 | |
| SCHEMBL8131456 | 0.85 | BCAT1 (0.36) | CCNE2CCNE1CDK2 | |
| SCHEMBL2012045 | 0.84 | ACHE (0.41) | KDM4EALDH1A1NOTUMNPC1MEN1 | |
| SCHEMBL8129047 | 0.84 | ACHE (0.41) | ALDH1A1NPC1MAPTHPGDHSD17B10 | |
| SCHEMBL28313472 | 0.84 | ALDH1A1 (0.50) | KDM4EALDH1A1IDO1NPC1DCUN1D1 | |
| SCHEMBL7822011 | 0.84 | CYP2A6 (0.39) | ALDH1A1IDO1NPC1KMT2APTPRC | |
| SCHEMBL434626 | 0.84 | KCNN4 (0.36) | KDM4EALDH1A1NOTUMIDO1NPC1 | |
| SCHEMBL9987691 | 0.84 | KDM4E (0.39) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2437987 | 0.81 | PDE3B (0.36) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117185953-A | Method for preparing chiral hydroxylamine by catalytic hydrogenation of oxime with asymmetric nickel | 上海交通大学 | 2023-12-08 | — | — | CN | claimed |
| US-9802921-B2 | Fluoromethyl-substituted pyrrole carboxamides iv | GRUENENTHAL GMBH (DE) | 2017-10-31 | — | — | US | claimed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | claimed |
| EP-1218358-B1 | THERAPEUTIC QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-09-13 | — | — | EP | claimed |
| US-20040102511-A1 | Substituted pyrrole derivatives | RANBAXY LABORATORIES LIMITED (IN) | 2004-05-27 | — | — | US | claimed |
| US-5120347-A | Pre and postemergence | ROHM AND HAAS COMPANY (US) | 1992-06-09 | — | — | US | claimed |
| CN-117185953-A | Method for preparing chiral hydroxylamine by catalytic hydrogenation of oxime with asymmetric nickel | 上海交通大学 | 2023-12-08 | — | — | CN | disclosed |
| US-20230150929-A1 | SELECTIVE NON-CYCLIC NUCLEOTIDE ACTIVATORS FOR THE CAMP SENSOR EPAC1 | UNIV TEXAS (US) | 2023-05-18 | — | — | US | disclosed |
| CN-114394913-B | Synthetic method of oxime ether derivative | 山东农业大学 | 2023-02-03 | — | — | CN | disclosed |
| EP-4121411-A1 | SELECTIVE NON-CYCLIC NUCLEOTIDE ACTIVATORS FOR THE CAMP SENSOR EPAC1 | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-01-25 | — | — | EP | disclosed |
| CN-109071504-B | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2022-03-08 | — | — | CN | disclosed |
| WO-2021188728-A1 | SELECTIVE NON-CYCLIC NUCLEOTIDE ACTIVATORS FOR THE CAMP SENSOR EPAC1 | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-09-23 | — | — | WO | disclosed |
| CN-105814022-A | Fused bicyclic heteroaromatic derivatives as modulators of tnf activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| US-20040102511-A1 | Substituted pyrrole derivatives | RANBAXY LABORATORIES LIMITED (IN) | 2004-05-27 | — | — | US | disclosed |
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4151302-A | Araliphatic dihalogen compounds composition and method of use | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-04-24 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |
| US-4057647-A | Araliphatic dihalogen compounds and process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230150929-A1 | SELECTIVE NON-CYCLIC NUCLEOTIDE ACTIVATORS FOR THE CAMP SENSOR EPAC1 | CREB1, RAPGEF4, ATF4 | KDM4E 3900/4885ALDH1A1 3629/4885NOTUM 3292/4885 |
| US-20040102511-A1 | Substituted pyrrole derivatives | HMGCR, PC, CYP46A1 | KDM4E 851/4885ALDH1A1 991/4885NOTUM 307/4885 |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | MAP3K1, MAP3K2, MAP3K7 | KDM4E 1970/4885ALDH1A1 3830/4885NOTUM 4023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.