SCHEMBL2012086

SCHEMBL2012086

CN(CCCNC(=O)CCc1ccccc1O)c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACKR3 P25106 1/20 0.54
GAA P10253 1/20 0.50
USP2 O75604 1/20 0.49
BCHE P06276 1/20 0.47
ALOX15 P16050 1/20 0.46
CYP2C19 P33261 2/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
GFER P55789 1/20 0.45
HPGD P15428 1/20 0.45
MMP2 P08253 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
CYP2C9 P11712 1/20 0.43
KDM4E B2RXH2 1/20 0.43
LMNA P02545 1/20 0.43
CNR1 P21554 1/20 0.43
ALDH1A1 P00352 1/20 0.42
MAPT P10636 1/20 0.42
TSHR P16473 1/20 0.42
MTNR1A P48039 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1986411 0.87 ALOX15 (0.55) ACKR3GAAALOX15CYP2C19HPGD
SCHEMBL9099535 0.84 USP2 (0.57) ACKR3GAAUSP2BCHEALOX15
SCHEMBL6807560 0.79 HPGD (0.48) ACKR3GAABCHEHPGDL3MBTL1
SCHEMBL4861149 0.78 USP2 (0.57) ACKR3GAAUSP2BCHEALOX15
SCHEMBL9549340 0.78 DNM1 (0.62) GAAUSP2BCHEHPGDMMP2
SCHEMBL5404064 0.78 LMNA (0.57) BCHEHPGDL3MBTL1KDM4ELMNA
SCHEMBL2001669 0.78 HPGD (0.65) HPGDMAPTMTNR1A
SCHEMBL27527714 0.78 HPGD (0.65) HPGDMAPTMTNR1A
SCHEMBL1984651 0.78 HPGD (0.49) ACKR3GAAHPGDMTNR1AMTNR1B
SCHEMBL1992751 0.76 ACKR3 (0.55) ACKR3GAAHPGDL3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1026150-B1 (2-oxy substituted)-phenylalkanamide derivative, hair growth promoter and external composition for skin using the same SHISEIDO CO LTD (JP) 2011-06-29 EP disclosed
US-6573297-B2 Applying an effective amount of (2-substituted oxyphenyl)alkanamide derivatives to the skin of a mammal for promoting hair growth SHISEIDO CO., LTD. (JP) 2003-06-03 US disclosed
US-20020052498-A1 (2-substituted oxyphenyl)alkanamide derivative, hair growth promoter and external composition for skin using the same SHISEIDO CO., LTD. (JP) 2002-05-02 US disclosed
US-6339154-B1 THERAPY OF HAIR LOSS IN MAMMALS AND, IN PARTICULAR, IN HUMAN SHISEIDO CO, LTD. (JP) 2002-01-15 US disclosed
EP-1026150-A1 (2-oxy substituted)-phenylalkanamide derivative, hair growth promoter and external composition for skin using the same SHISEIDO COMPANY LIMITED (JP) 2000-08-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020052498-A1 (2-substituted oxyphenyl)alkanamide derivative, hair growth promoter and external composition for skin using the same NR2E1, NCOR2, DECR2 ACKR3 802/4885GAA 4713/4885USP2 2786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.