Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | VNN1 | O95497 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16615938 | 0.74 | GRIN2A (0.51) | GPR139PDE10AGRM5VNN1ALDH1A1 | |
| SCHEMBL16615837 | 0.73 | VNN1 (0.48) | GRM5VNN1ALDH1A1GAAROCK2 | |
| SCHEMBL16615922 | 0.72 | GRIN2A (0.54) | GPR139PDE10AGRM5VNN1ALDH1A1 | |
| SCHEMBL16615939 | 0.62 | GRIN2A (0.58) | ALDH1A1GAAROCK2 | |
| SCHEMBL6203164 | 0.62 | GPR139 (0.57) | GPR139GRM5ALDH1A1GAAMCHR1 | |
| SCHEMBL6973660 | 0.62 | GSK3B (0.55) | GPR139GRM5VNN1ALDH1A1GAA | |
| SCHEMBL16615798 | 0.61 | HPGD (0.47) | ALDH1A1GAAROCK2 | |
| SCHEMBL11833937 | 0.61 | CYP1A2 (0.61) | ALDH1A1GAA | |
| SCHEMBL17142140 | 0.61 | HDAC2 (0.64) | GPR139VNN1ALDH1A1GAAMAOA | |
| SCHEMBL17441717 | 0.61 | NAMPT (0.51) | GPR139GRM5VNN1GAAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963434-B2 | N-arylmethyl sulfonamide negative modulators of NR2A | LUC THERAPEUTICS, INC. (US) | 2018-05-08 | — | — | US | disclosed |