Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20123640 | 0.87 | NOTUM (0.36) | NOTUMTAAR1HSD17B3ADRA2ACYP2D6 | |
| SCHEMBL20123590 | 0.87 | DRD2 (0.32) | NOTUMDRD2DRD3TAAR1ADRA2A | |
| SCHEMBL20123623 | 0.86 | NOTUM (0.42) | NOTUMDRD2DRD3 | |
| SCHEMBL20015248 | 0.78 | HSD17B3 (0.39) | DRD2DRD3HSD17B3ADRA2ACYP2D6 | |
| SCHEMBL20014575 | 0.77 | ADRA2A (0.33) | NOTUMTAAR1ADRA2ACYP2D6ADRA2B | |
| SCHEMBL20123586 | 0.75 | MEN1 (0.33) | HSD17B3GAA | |
| SCHEMBL19939720 | 0.75 | ALDH1A1 (0.34) | NOTUMDRD2DRD3HSD17B3ADRA2A | |
| SCHEMBL20015251 | 0.73 | NOTUM (0.36) | NOTUMDRD2DRD3 | |
| SCHEMBL1912510 | 0.72 | — | — | |
| SCHEMBL20123600 | 0.71 | ADRA2A (0.33) | HSD17B3ADRA2ACYP2D6ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620436-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO (JP) | 2018-05-09 | — | — | EP | disclosed |