Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20123632 | 0.86 | MEN1 (0.37) | MEN1KMT2ANPC1LMNATP53 | |
| SCHEMBL20123590 | 0.81 | DRD2 (0.32) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL20123649 | 0.81 | ACHE (0.35) | NPSR1MEN1KMT2ANPC1LMNA | |
| SCHEMBL20015248 | 0.78 | HSD17B3 (0.39) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL20014517 | 0.75 | MEN1 (0.43) | ADRA2ACYP2D6ADRA2BADRA2CADRA1A | |
| SCHEMBL20014575 | 0.74 | ADRA2A (0.33) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL20014809 | 0.74 | ADRA2A (0.33) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL20123824 | 0.74 | MEN1 (0.34) | MEN1KMT2ANPC1LMNATP53 | |
| SCHEMBL20123727 | 0.74 | ACHE (0.35) | NPSR1MEN1KMT2ANPC1LMNA | |
| SCHEMBL20123626 | 0.71 | NOTUM (0.36) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620436-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO (JP) | 2018-05-09 | — | — | EP | disclosed |