Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27546271 | 0.82 | BRD4 (0.61) | LMNACYP2D6BRD4RAB9AALDH1A1 | |
| SCHEMBL3860865 | 0.82 | ALDH1A1 (0.54) | CCR1RAB9AALDH1A1MAPT | |
| SCHEMBL27566272 | 0.81 | KDM4E (0.44) | CCR1LMNACYP2D6BRD4ALDH1A1 | |
| SCHEMBL9197891 | 0.80 | PKM (0.54) | CCR1LMNABRD4RAB9AALDH1A1 | |
| SCHEMBL24535027 | 0.79 | LMNA (0.48) | CCR1LMNABRD4ALDH1A1 | |
| SCHEMBL6215373 | 0.79 | ALDH1A1 (0.50) | CCR1LMNABRD4RAB9AALDH1A1 | |
| SCHEMBL27524695 | 0.79 | BRD4 (0.47) | CCR1LMNABRD4ALDH1A1MAPT | |
| SCHEMBL4796147 | 0.77 | ALDH1A1 (0.59) | ALDH1A1MAPT | |
| SCHEMBL29760424 | 0.77 | ALDH1A1 (0.59) | ALDH1A1MAPT | |
| SCHEMBL8926580 | 0.77 | BRD4 (0.74) | LMNABRD4RAB9ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970275-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2018-05-09 | — | — | EP | disclosed |
| CN-1326858-C | tricyclic spiropiperidine compounds | ASTRAZENECA AB (SE) | 2007-07-18 | — | — | CN | disclosed |
| CN-1974574-A | Novel tricyclic spiropiperidines or spiropyrrolidines | ASTRAZENECA AB (SE) | 2007-06-06 | — | — | CN | disclosed |
| CN-1894232-A | Novel tricyclic spiroderivatives as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2007-01-10 | — | — | CN | disclosed |
| CN-1675218-A | Novel tricyclic spiropiperidines or spiropyrrolidines | ASTRAZENECA AB (SE) | 2005-09-28 | — | — | CN | disclosed |