SCHEMBL20125003

SCHEMBL20125003

CC1=Cc2cccc(F)c2C1

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.34
PGR P06401 2/20 0.32
NOTUM Q6P988 1/20 0.32
DRD2 P14416 1/20 0.31
DRD3 P35462 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30667121 0.78 CYP2A6 (0.35) ACHENOTUM
SCHEMBL5953457 0.78 CYP2A6 (0.35) ACHENOTUM
SCHEMBL1319720 0.75 TRPA1 (0.41)
SCHEMBL1452615 0.75 ADRA2A (0.36) NOTUM
SCHEMBL12122310 0.75
SCHEMBL31359427 0.75 TRPA1 (0.41)
SCHEMBL4275973 0.73 PTGS2 (0.32) DRD2DRD3
SCHEMBL12319663 0.73 TAAR1 (0.46) DRD2DRD3
SCHEMBL18033909 0.72
SCHEMBL5953568 0.72 GABRA1 (0.39) DRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3318557-A2 QUINOLONE COMPOUND Otsuka Pharmaceutical Co., Ltd. (JP) 2018-05-09 EP disclosed