SCHEMBL20127459

SCHEMBL20127459

c1cc(-c2c3ccccc3c(-c3c4ccccc4cc4c3oc3ccccc34)c3ccccc23)cc(-c2cc3ccccc3c3ccccc23)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 5/20 0.39
CYP11B1 P15538 1/20 0.38
AHR P35869 1/20 0.35
GPR84 Q9NQS5 5/20 0.35
KDM4E B2RXH2 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
GGPS1 O95749 1/20 0.34
GAPDH P04406 1/20 0.34
MAPT P10636 1/20 0.34
PIK3CD O00329 1/20 0.33
XRCC6 P12956 1/20 0.33
XRCC5 P13010 1/20 0.33
PIK3CA P42336 1/20 0.33
PRKDC P78527 1/20 0.33
ALDH1A1 P00352 2/20 0.33
MAOB P27338 1/20 0.33
RAB9A P51151 1/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20127662 0.94 ALOX5 (0.40) ALOX5CYP11B1AHRGPR84KDM4E
SCHEMBL10122586 0.91 ALOX5 (0.37) ALOX5CYP11B1AHRGPR84KDM4E
SCHEMBL20127463 0.90 ALOX5 (0.51) ALOX5AHRGPR84KDM4EMEN1
SCHEMBL10122556 0.90 ALOX5 (0.42) ALOX5AHRGPR84KDM4EMEN1
SCHEMBL20127450 0.90 ALOX5 (0.38) ALOX5CYP11B1AHRGPR84KDM4E
SCHEMBL10122558 0.88 PLA2G2A (0.40) ALOX5AHRGPR84KDM4EMEN1
SCHEMBL10122695 0.88 AHR (0.41) ALOX5AHRGPR84KDM4EMEN1
SCHEMBL20127425 0.87 ALOX5 (0.42) ALOX5CYP11B1AHRGPR84KDM4E
SCHEMBL20127456 0.87 PLA2G2A (0.38) ALOX5AHRGPR84KDM4EMEN1
SCHEMBL10122477 0.87 ALOX5 (0.42) ALOX5CYP11B1AHRGPR84KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180208836-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT AND ELECTRONIC DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2018-07-26 US disclosed
US-20180208836-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT AND ELECTRONIC DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2018-07-26 US disclosed
US-20180130968-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT AND ELECTRONIC DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2018-05-10 US disclosed
US-20180130968-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT AND ELECTRONIC DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2018-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180130968-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT AND ELECTRONIC DEVICE RER1, NR0B1, NR2E1 ALOX5 4115/4885CYP11B1 483/4885AHR 2558/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.