SCHEMBL2012933

SCHEMBL2012933

Cc1ccc[c]c1-c1cc(F)cc(F)c1

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.37
MGAM O43451 1/20 0.31
GAA P10253 1/20 0.31
SI P14410 1/20 0.31
MGAM2 Q2M2H8 1/20 0.31
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2012944 0.85 MGAM (0.42) ACHEMGAMGAASIMGAM2
SCHEMBL2011907 0.82 KDM4E (0.38) ACHEMGAMGAASIMGAM2
SCHEMBL2431963 0.78 ACHE (0.34) ACHEGAAKDM4EALDH1A1
SCHEMBL10936903 0.77 ESR2 (0.33) MGAMGAASIMGAM2
SCHEMBL6581072 0.77 LMNA (0.35) GAAKDM4EALDH1A1
SCHEMBL2015118 0.77 MAPK1 (0.30)
SCHEMBL2884608 0.76 ACHE (0.42) ACHEALDH1A1
SCHEMBL981110 0.75 TSHR (0.39) ACHEALDH1A1
SCHEMBL2013153 0.74 HTR1A (0.35) ACHE
SCHEMBL5984201 0.74 METAP2 (0.35) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013182433-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-12-12 WO disclosed
EP-2547687-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-01-23 EP disclosed
EP-2513067-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2012-10-24 EP disclosed
WO-2011113820-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2011-09-22 WO disclosed
WO-2011073145-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2011-06-23 WO disclosed