Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018364 | 0.76 | KDM4E (0.39) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL7950881 | 0.74 | KDM4E (0.41) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL29977012 | 0.70 | HTT (0.50) | KMT2AMEN1TRPM8ALDH1A1HPGD | |
| SCHEMBL22116897 | 0.70 | HTT (0.50) | KMT2AMEN1TRPM8ALDH1A1HPGD | |
| SCHEMBL307472 | 0.70 | P2RX7 (0.50) | KDM4ELMNATRPM8ALDH1A1ALOX15 | |
| SCHEMBL3922378 | 0.70 | PARP1 (0.55) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL643192 | 0.69 | ALDH1A1 (0.46) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL2017299 | 0.69 | ALDH1A1 (0.60) | ALDH1A1 | |
| SCHEMBL2308777 | 0.68 | TRPM8 (0.38) | KDM4ELMNAKMT2AMEN1TRPM8 | |
| SCHEMBL361516 | 0.68 | ALOX15 (0.65) | LMNAKMT2AMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |