Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017454 | 0.80 | L3MBTL1 (0.41) | KDM4EHIF1ACYP3A4ALOX12TDP1 | |
| SCHEMBL2013290 | 0.76 | KDM4E (0.35) | KDM4ETDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL2014967 | 0.72 | KMT2A (0.54) | KDM4EGAAHIF1ACYP3A4ALOX12 | |
| SCHEMBL7072815 | 0.71 | KDM4E (0.40) | KDM4EGAACYP3A4ALOX12TDP1 | |
| SCHEMBL29120017 | 0.71 | CCR1 (0.40) | KDM4EHIF1ACYP3A4ALOX12TDP1 | |
| SCHEMBL7302758 | 0.68 | L3MBTL1 (0.46) | KDM4EHIF1ACYP3A4ALOX12TDP1 | |
| SCHEMBL257468 | 0.68 | LMNA (0.54) | TDP1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL29865799 | 0.68 | LMNA (0.54) | TDP1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL307472 | 0.66 | P2RX7 (0.50) | KDM4ECYP3A4TDP1ALDH1A1NPSR1 | |
| SCHEMBL2308777 | 0.65 | TRPM8 (0.38) | KDM4EGAACYP3A4TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |