Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17286157 | 0.78 | NPC1 (0.33) | CYP2D6ACEHTT | |
| SCHEMBL13810242 | 0.73 | SLC6A2 (0.32) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL19175977 | 0.69 | ALDH1A1 (0.35) | HTT | |
| SCHEMBL12621094 | 0.69 | CHRNB2 (0.30) | — | |
| SCHEMBL1827466 | 0.69 | ALDH1A1 (0.35) | HTT | |
| SCHEMBL27744281 | 0.67 | CHRNB2 (0.36) | — | |
| SCHEMBL24411157 | 0.66 | GAA (0.32) | — | |
| SCHEMBL164696 | 0.65 | SIRT1 (0.32) | — | |
| SCHEMBL18487402 | 0.65 | HCAR2 (0.39) | — | |
| SCHEMBL1463307 | 0.64 | CHRNB2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10808007-B2 | Desacetoxytubulysin H and analogs thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2020-10-20 | — | — | US | disclosed |
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | REN, MAN2B2, UTS2R | SLC6A3 502/4885SLC6A2 1221/4885CYP3A4 503/4885 |
| US-10808007-B2 | Desacetoxytubulysin H and analogs thereof | REN, MAN2B2, UTS2R | SLC6A3 502/4885SLC6A2 1221/4885CYP3A4 503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.