Sugi Predict

Sugi Predict / Compounds / SCHEMBL20135710

SCHEMBL20135710

SCHEMBL20135710

CC[C@@]1(c2ccc(C(=O)N3CCN(c4ncc(C)cc4C)CC3)cn2)CC(=O)NC1=O

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.38
▸ ALDH1A1 P00352 1/20 0.37
▸ RAB9A P51151 2/20 0.37
▸ KDM4E B2RXH2 2/20 0.35
▸ KMT2A Q03164 3/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ MAPT P10636 2/20 0.35
▸ CFTR P13569 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ TP53 P04637 1/20 0.35
▸ CRBN Q96SW2 1/20 0.34
▸ PIK3CG P48736 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ GRM5 P41594 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ P2RY12 Q9H244 1/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ SLC6A7 Q99884 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29688381 1.00 HPGD (0.38) HPGDALDH1A1RAB9AKDM4EKMT2A
SCHEMBL20135291 1.00 HPGD (0.38) HPGDALDH1A1RAB9AKDM4EKMT2A
SCHEMBL20135298 1.00 HPGD (0.38) HPGDALDH1A1RAB9AKDM4EKMT2A
SCHEMBL20135226 0.91 RAB9A (0.37) HPGDALDH1A1RAB9AKDM4EKMT2A
SCHEMBL29688438 0.91 RAB9A (0.37) HPGDALDH1A1RAB9AKDM4EKMT2A
SCHEMBL20135231 0.91 RAB9A (0.37) HPGDALDH1A1RAB9AKDM4EKMT2A
SCHEMBL20135717 0.91 RAB9A (0.37) HPGDALDH1A1RAB9AKDM4EKMT2A
SCHEMBL29689169 0.89 CYP19A1 (0.42) HPGDALDH1A1KDM4EKMT2AMEN1
SCHEMBL20134960 0.89 CYP19A1 (0.42) HPGDALDH1A1KDM4EKMT2AMEN1
SCHEMBL20134962 0.89 CYP19A1 (0.42) HPGDALDH1A1KDM4EKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107922347-B Novel imide derivatives and their use as pharmaceuticals 田边三菱制药株式会社 2022-06-28 — — CN disclosed
US-10407408-B2 Imide derivatives and use thereof as medicine MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-09-10 — — US disclosed
US-10407408-B2 Imide derivatives and use thereof as medicine MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-09-10 — — US disclosed
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-03-14 — — US disclosed
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-03-14 — — US disclosed
EP-3321256-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2018-05-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MMP9, MMP10, MMP1 HPGD 74/4885ALDH1A1 584/4885RAB9A 270/4885
US-10407408-B2 Imide derivatives and use thereof as medicine MMP9, MMP2, MMP1 HPGD 75/4885ALDH1A1 610/4885RAB9A 345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.