Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.32 |
| ▸ | TUBB | P07437 | 2/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.32 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.32 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.32 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.32 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.32 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18471539 | 0.76 | NOS3 (0.46) | OPRK1BRD4HCRTR1HCRTR2CFTR | |
| SCHEMBL16031783 | 0.74 | HCRTR1 (0.45) | OPRK1BRD4HCRTR1HCRTR2TUBB4A | |
| SCHEMBL20135895 | 0.73 | CCR1 (0.39) | OPRK1BRD4HCRTR1KMT2ACCR1 | |
| SCHEMBL20135913 | 0.72 | BRD4 (0.38) | BRD4HCRTR1HCRTR2HPGDSPIN1 | |
| SCHEMBL1289874 | 0.68 | ALDH1A1 (0.42) | BRD4TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1206724 | 0.68 | NOS3 (0.46) | KMT2ACCR1CCR5CCR8 | |
| SCHEMBL13114685 | 0.66 | HPGDS (0.47) | OPRK1BRD4TUBB4ATUBBTUBA3C | |
| SCHEMBL5210212 | 0.66 | KDM4E (0.37) | OPRK1BRD4TUBB4ATUBBTUBA3C | |
| SCHEMBL3725066 | 0.66 | BRD4 (0.38) | BRD4HCRTR1HCRTR2TUBB4ATUBB | |
| SCHEMBL20278394 | 0.66 | HPGDS (0.33) | OPRK1HCRTR1HCRTR2HPGDSKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | claimed |