Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.64 |
| ▸ | CTSK | P43235 | 4/20 | 0.64 |
| ▸ | CTSL | P07711 | 3/20 | 0.64 |
| ▸ | CTSB | P07858 | 3/20 | 0.64 |
| ▸ | SYK | P43405 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TACR1 | P25103 | 2/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485661 | 1.00 | CTSS (0.64) | CTSSCTSKCTSLCTSBSYK | |
| SCHEMBL11973516 | 0.92 | ITGB3 (0.59) | CTSSCTSKCTSLCTSBSYK | |
| SCHEMBL11973513 | 0.92 | ITGB3 (0.59) | CTSSCTSKCTSLCTSBSYK | |
| SCHEMBL15901012 | 0.91 | KLKB1 (0.61) | — | |
| SCHEMBL17268092 | 0.91 | KLKB1 (0.61) | — | |
| SCHEMBL6482274 | 0.89 | CTSS (0.66) | CTSSCTSKCTSLCTSBSYK | |
| SCHEMBL23529664 | 0.89 | CTSS (0.64) | CTSSCTSKCTSLCTSBMAPT | |
| SCHEMBL3383006 | 0.89 | CTSS (0.77) | CTSSCTSKCTSLCTSBAKT1 | |
| SCHEMBL7762796 | 0.89 | CTSL (0.74) | CTSSCTSKCTSLCTSBMAPT | |
| SCHEMBL15900595 | 0.88 | PSMB1 (0.57) | CTSSCTSKCTSLCTSBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729443-B3 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-02-12 | — | — | EP | disclosed |
| EP-2870137-B1 | POLYMORPHS OF N-[(R)-1-[(S)-1-(4-AMINOMETHYL-BENZYLCARBAMOYL)-2-PHENYL-ETHYLCARBAMOYL]-2-(4-ETHOXY-PHENYL)-ETHYL]-BENZAMIDE HYDROCHLORIDE | KALVISTA PHARMACEUTICALS LTD (GB) | 2018-05-16 | — | — | EP | disclosed |