Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2020767 | 0.83 | ACSS2 (0.54) | TNFTSHRACSS2HTTMAPT | |
| SCHEMBL2013679 | 0.83 | PPARG (0.45) | TNFTSHRACSS2HTTMEN1 | |
| SCHEMBL13273918 | 0.82 | ALDH1A1 (0.54) | TNFTSHRTLR8RAB9AMEN1 | |
| SCHEMBL25466809 | 0.80 | TLR8 (0.48) | ACSS2TLR8HTTMAPTGAA | |
| SCHEMBL2020612 | 0.80 | ACSS2 (0.56) | ACSS2MAPTRAB9AKMT2ANPC1 | |
| SCHEMBL23638515 | 0.80 | RAB9A (0.49) | TNFTSHRACSS2TLR8MAPT | |
| SCHEMBL2018097 | 0.80 | HTT (0.59) | ACSS2HTTMAPTRAB9AMEN1 | |
| SCHEMBL13559769 | 0.80 | KCNH2 (0.70) | TNFTSHRHTTMAPTRAB9A | |
| SCHEMBL21803210 | 0.80 | ACSS2 (0.55) | TSHRACSS2TLR8HTTMAPT | |
| SCHEMBL2015276 | 0.79 | PPARG (0.49) | TNFTSHRACSS2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |