Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139617 | 0.81 | HDAC4 (0.41) | HDAC4HPGDHSD17B10ROCK2 | |
| SCHEMBL20139709 | 0.76 | HDAC4 (0.38) | HDAC4 | |
| SCHEMBL21229255 | 0.74 | MAPK9 (0.37) | KMT2A | |
| SCHEMBL20139663 | 0.70 | ROCK2 (0.39) | HDAC4HPGDHSD17B10KMT2AROCK2 | |
| SCHEMBL5739585 | 0.66 | HDAC4 (0.34) | HDAC4HPGDHSD17B10 | |
| SCHEMBL5071497 | 0.64 | NFE2L2 (0.38) | HDAC4KMT2A | |
| SCHEMBL20161327 | 0.64 | NPC1 (0.38) | — | |
| SCHEMBL11215460 | 0.62 | SLC6A2 (0.52) | — | |
| SCHEMBL11215459 | 0.62 | SLC6A2 (0.52) | — | |
| SCHEMBL1515803 | 0.62 | SLC6A2 (0.39) | HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538520-A2 | SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |