Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5071497 | 0.83 | NFE2L2 (0.38) | HDAC4NFE2L2CES2CES1 | |
| SCHEMBL20139680 | 0.81 | HDAC4 (0.39) | HDAC4HPGDHSD17B10ROCK2 | |
| SCHEMBL1515803 | 0.78 | SLC6A2 (0.39) | HPGDGAA | |
| SCHEMBL9347326 | 0.76 | CES2 (0.42) | NFE2L2CES2CES1GAA | |
| SCHEMBL20139604 | 0.74 | HDAC4 (0.40) | HDAC4MAPKAPK2CES2CES1 | |
| SCHEMBL20139663 | 0.73 | ROCK2 (0.39) | HDAC4HPGDHSD17B10ROCK2ALOX5AP | |
| SCHEMBL15109715 | 0.70 | HDAC4 (0.39) | HDAC4NFE2L2CES2CES1 | |
| SCHEMBL1515751 | 0.70 | IDO1 (0.46) | CES2CES1GAA | |
| SCHEMBL5739585 | 0.69 | HDAC4 (0.34) | HDAC4HPGDHSD17B10CES2CES1 | |
| SCHEMBL14743495 | 0.67 | CES2 (0.36) | HDAC4NFE2L2CES2CES1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538520-A2 | SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |