Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | ERG | P11308 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | USP28 | Q96RU2 | 9/20 | 0.38 |
| ▸ | USP25 | Q9UHP3 | 7/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28256718 | 0.83 | USP28 (0.52) | NAMPTAKT1DRD2USP28USP25 | |
| SCHEMBL28256724 | 0.82 | USP28 (0.53) | NAMPTDRD2USP28USP25 | |
| SCHEMBL28258182 | 0.80 | USP28 (0.56) | NAMPTDRD2USP28USP25 | |
| SCHEMBL22957300 | 0.80 | NAMPT (0.51) | NAMPTCA1CA2USP28USP25 | |
| SCHEMBL13171671 | 0.79 | NSD2 (0.46) | NAMPTCA1CA2 | |
| SCHEMBL20157263 | 0.79 | NQO2 (0.44) | NAMPTDRD2ACACBACACA | |
| SCHEMBL20141383 | 0.78 | TRPA1 (0.52) | NAMPTCA1CA2 | |
| SCHEMBL31432911 | 0.78 | CA1 (0.48) | CA1CA2 | |
| SCHEMBL31432797 | 0.77 | CA1 (0.47) | CA1CA2 | |
| SCHEMBL20140237 | 0.76 | TMEM97 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |