Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20555936 | 0.84 | HTR1A (0.53) | HTTCHRM4CHRM2CA12CA1 | |
| SCHEMBL5390221 | 0.83 | CA12 (0.46) | HTTCA12CA1CA2CA9 | |
| SCHEMBL12684798 | 0.80 | KDM4E (0.64) | HTTMAPK1LMNATSHRALDH1A1 | |
| SCHEMBL28094905 | 0.78 | LMNA (0.43) | HTTCA12CA1CA2CA9 | |
| SCHEMBL11297155 | 0.78 | IP6K1 (0.49) | HTTCA12CA1CA2CA9 | |
| SCHEMBL15066929 | 0.78 | HTT (0.38) | HTTCA12CA1CA2CA9 | |
| SCHEMBL27643076 | 0.77 | SLC6A9 (0.52) | HTTCA12CA1CA2CA9 | |
| SCHEMBL5414205 | 0.77 | CHRM2 (0.52) | HTTCHRM4CHRM2CA12CA1 | |
| SCHEMBL3760556 | 0.76 | MAPT (0.43) | HTTCA12CA1CA2CA9 | |
| SCHEMBL2229043 | 0.76 | ADAMTS5 (0.42) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |