Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129629 | 0.82 | CRBN (0.53) | ALDH1A1CRBNLMNAMAPT | |
| SCHEMBL20129632 | 0.80 | AHR (0.50) | AHRDRD2DRD4DRD3HTR1A | |
| SCHEMBL20156848 | 0.74 | HTR7 (0.42) | AHRDRD2DRD4DRD3HTR1A | |
| SCHEMBL5373690 | 0.71 | BACE1 (0.50) | ALDH1A1CRBNLMNAMAPT | |
| SCHEMBL11087705 | 0.71 | KDM4E (0.49) | ALDH1A1KDM4EALOX15CYP1A2CYP2C9 | |
| SCHEMBL27237928 | 0.70 | HTR1A (0.49) | DRD2DRD3HTR1AHTR2AALDH1A1 | |
| SCHEMBL27237941 | 0.69 | KDM4E (0.40) | DRD2DRD3ALDH1A1KDM4EALOX15 | |
| SCHEMBL9374810 | 0.69 | AHR (0.56) | AHRSMYD3GRM5ALDH1A1ALOX15 | |
| SCHEMBL11195055 | 0.69 | ALDH1A1 (0.49) | ALDH1A1KDM4EKMT2AMEN1LMNA | |
| SCHEMBL27973682 | 0.69 | ALDH1A1 (0.37) | DRD2DRD3ALDH1A1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |