Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.54 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.54 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140044 | 0.92 | MTOR (0.54) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20142065 | 0.87 | KDM4E (0.51) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20139934 | 0.87 | PPARG (0.47) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20156931 | 0.87 | MTOR (0.51) | MTORRPTORMLST8USP2SMN1; SMN2 | |
| SCHEMBL20140785 | 0.87 | PARP1 (0.47) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20139930 | 0.87 | MTOR (0.53) | MTORRPTORMLST8USP2MAPK1 | |
| SCHEMBL20140716 | 0.87 | MTOR (0.53) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20140693 | 0.84 | HCRTR1 (0.49) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20139909 | 0.84 | LMNA (0.52) | MTORRPTORMLST8MAPK1SMN1; SMN2 | |
| SCHEMBL20141182 | 0.84 | PARP1 (0.48) | MTORRPTORMLST8SMN1; SMN2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |