Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.48 |
| ▸ | MTOR | P42345 | 4/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140590 | 0.89 | PARP1 (0.49) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20140865 | 0.89 | MTOR (0.48) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20140044 | 0.88 | MTOR (0.54) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20140472 | 0.87 | PARP1 (0.46) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20139934 | 0.87 | PPARG (0.47) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20140585 | 0.85 | PPARG (0.47) | PARP1MTORRPTORMLST8TACR3 | |
| SCHEMBL20156887 | 0.85 | PPARG (0.46) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20156963 | 0.85 | GBA1 (0.45) | PARP1MTORRPTORMLST8 | |
| SCHEMBL20140304 | 0.85 | GBA1 (0.44) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20140693 | 0.84 | HCRTR1 (0.49) | PARP1MTORRPTORMLST8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |