Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6023940 | 0.78 | ADRA2C (0.49) | DRD2HTR7LATS1KDM4EHDAC1 | |
| SCHEMBL17739047 | 0.75 | LATS1 (0.34) | LATS1HDAC1ARROCK1CDC42BPB | |
| SCHEMBL233169 | 0.75 | ADRB1 (0.58) | DRD2HTR7HTR1AKDM4EADRB1 | |
| SCHEMBL22914763 | 0.75 | KDM4E (0.47) | DRD2LATS1KDM4EADRB1DRD3 | |
| SCHEMBL17738344 | 0.74 | LATS1 (0.33) | LATS1HDAC1ARROCK1CDC42BPB | |
| Hydrochloric Acid SCHEMBL20139829 | 0.74 | ADRB1 (0.56) | DRD2HTR7HTR1AKDM4EADRB1 | |
| SCHEMBL19035611 | 0.74 | HTR3E (0.52) | HTR7HTR1ALATS1HDAC1CSNK1E | |
| Hydrochloric Acid SCHEMBL29882725 | 0.74 | ADRB1 (0.56) | DRD2HTR7HTR1AKDM4EADRB1 | |
| SCHEMBL31432913 | 0.73 | ALDH1A1 (0.44) | DRD2HTR1AGRM5OPRM1OPRL1 | |
| SCHEMBL31432940 | 0.72 | ALDH1A1 (0.51) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |