Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | SLC27A1 | Q6PCB7 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141517 | 0.85 | KDM4E (0.49) | KDM4ELMNASMN1; SMN2HTTMEN1 | |
| SCHEMBL20140053 | 0.84 | GRM1 (0.53) | — | |
| SCHEMBL20157096 | 0.84 | GRM1 (0.53) | — | |
| SCHEMBL20157095 | 0.84 | GRM1 (0.53) | — | |
| SCHEMBL20140074 | 0.83 | MAPT (0.50) | KDM4ELMNAALDH1A1HRH3PPARG | |
| SCHEMBL20140026 | 0.83 | KDM4E (0.57) | KDM4ELMNASMN1; SMN2HTTMEN1 | |
| SCHEMBL25317158 | 0.81 | MEN1 (0.46) | KDM4ELMNASMN1; SMN2HTTMEN1 | |
| SCHEMBL29475509 | 0.81 | MEN1 (0.46) | KDM4ELMNASMN1; SMN2HTTMEN1 | |
| SCHEMBL20140681 | 0.78 | ALDH1A1 (0.52) | KDM4ELMNAHTTMEN1CYP1A2 | |
| SCHEMBL20141007 | 0.76 | PKM (0.48) | KDM4ELMNASMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |