Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141892 | 0.82 | PKM (0.47) | PKMPOLBGPR119L3MBTL1KDM4E | |
| SCHEMBL20139858 | 0.82 | PKM (0.47) | PKMPOLBGPR119L3MBTL1KDM4E | |
| SCHEMBL20140581 | 0.76 | KDM4E (0.52) | KDM4ELMNASMN1; SMN2ALDH1A1PPARG | |
| SCHEMBL20140074 | 0.72 | MAPT (0.50) | POLBGPR119L3MBTL1KDM4ELMNA | |
| SCHEMBL20141897 | 0.72 | HTT (0.47) | PKMPOLBKDM4EGAAALDH1A1 | |
| SCHEMBL20139969 | 0.71 | MTOR (0.49) | KDM4ELMNASMN1; SMN2GAARAB9A | |
| SCHEMBL20139954 | 0.70 | POLB (0.45) | PKMPOLBL3MBTL1KDM4ELMNA | |
| SCHEMBL20157096 | 0.69 | GRM1 (0.53) | — | |
| SCHEMBL20157095 | 0.69 | GRM1 (0.53) | — | |
| SCHEMBL20140053 | 0.69 | GRM1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |