Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140662 | 1.00 | ROCK2 (0.50) | ROCK2ROCK1PRKCQPRKCDKIT | |
| SCHEMBL20157192 | 0.81 | KIT (0.42) | ROCK2ROCK1PRKCQPRKCDKIT | |
| SCHEMBL20157193 | 0.81 | KIT (0.42) | ROCK2ROCK1PRKCQPRKCDKIT | |
| SCHEMBL20141025 | 0.80 | HTR2C (0.56) | ROCK2ROCK1 | |
| SCHEMBL20141437 | 0.78 | HTR1A (0.44) | ROCK2ROCK1PRKCQPRKCDPRKCI | |
| SCHEMBL20141435 | 0.78 | HTR1A (0.44) | ROCK2ROCK1PRKCQPRKCDPRKCI | |
| SCHEMBL6281370 | 0.77 | HTR2C (0.65) | PRKCQPRKCDKITHRH4 | |
| SCHEMBL6271843 | 0.77 | HTR2C (0.65) | PRKCQPRKCDKITHRH4 | |
| SCHEMBL3683893 | 0.76 | HTR2C (0.47) | ROCK2PRKCQPRKCDKITHRH4 | |
| SCHEMBL3683532 | 0.75 | HDAC2 (0.44) | ROCK2PRKCQPRKCDKITHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |