Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 6/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140785 | 0.90 | PARP1 (0.47) | PARP1KDM4EALDH1A1HTTMTOR | |
| SCHEMBL20139867 | 0.90 | PARP1 (0.49) | PARP1KDM4EALDH1A1HTTMTOR | |
| SCHEMBL20140727 | 0.89 | MTOR (0.47) | PARP1KDM4EALDH1A1HTTMTOR | |
| SCHEMBL20141182 | 0.87 | PARP1 (0.48) | PARP1KDM4EALDH1A1HTTMTOR | |
| SCHEMBL20140044 | 0.86 | MTOR (0.54) | PARP1KDM4EALDH1A1HTTMTOR | |
| SCHEMBL20157021 | 0.86 | SLC6A7 (0.46) | PARP1KDM4EALDH1A1MTORRPTOR | |
| SCHEMBL20140693 | 0.86 | HCRTR1 (0.49) | PARP1KDM4EALDH1A1HTTMTOR | |
| SCHEMBL20141809 | 0.85 | GBA1 (0.44) | PARP1KDM4EALDH1A1HTTMTOR | |
| SCHEMBL20139934 | 0.84 | PPARG (0.47) | PARP1KDM4EALDH1A1HTTMTOR | |
| SCHEMBL20140587 | 0.82 | MTOR (0.54) | PARP1KDM4EALDH1A1HTTMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |