Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016907 | 0.81 | KDM4E (0.44) | KDM4ELMNAMAPTALOX15TSHR | |
| SCHEMBL2010932 | 0.80 | KDM4E (0.43) | KDM4ELMNAMAPTALOX15TSHR | |
| SCHEMBL2016022 | 0.79 | CCR1 (0.39) | KDM4ELMNAMAPTALOX15TSHR | |
| SCHEMBL2017973 | 0.78 | L3MBTL1 (0.43) | KDM4ELMNAMAPTALOX15HTT | |
| SCHEMBL3904765 | 0.75 | DPP4 (0.42) | KDM4ELMNATDP1NPC1MEN1 | |
| SCHEMBL2014256 | 0.72 | ALDH1A1 (0.44) | KDM4ELMNAMAPTALOX15TSHR | |
| SCHEMBL6225626 | 0.72 | KDM4E (0.48) | KDM4ELMNAMAPTALOX15TSHR | |
| SCHEMBL1812109 | 0.69 | KDM1A (0.40) | KDM4ETDP1ALDH1A1NPC1MEN1 | |
| SCHEMBL29796409 | 0.69 | KDM1A (0.40) | KDM4ETDP1ALDH1A1NPC1MEN1 | |
| SCHEMBL2010930 | 0.69 | TP53 (0.44) | KDM4ELMNAMAPTALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |