Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR6 | P46095 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012835 | 0.88 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ETDP1KMT2A | |
| SCHEMBL2015986 | 0.86 | L3MBTL1 (0.48) | ALDH1A1KDM4ETDP1KMT2AMAPT | |
| SCHEMBL2014858 | 0.86 | KDM4E (0.55) | ALDH1A1TSHRKDM4EKMT2AMAPT | |
| SCHEMBL2015058 | 0.84 | GBA1 (0.45) | ALDH1A1KDM4ETDP1KMT2AMAPT | |
| SCHEMBL2163140 | 0.84 | ALDH1A1 (0.55) | ALDH1A1TSHRKDM4ETDP1KMT2A | |
| SCHEMBL2013930 | 0.83 | AKR1C3 (0.43) | ALDH1A1KDM4ETDP1KMT2AMAPT | |
| SCHEMBL2016804 | 0.83 | SLC6A7 (0.47) | ALDH1A1TSHRKDM4ETDP1KMT2A | |
| SCHEMBL2164787 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ETDP1KMT2A | |
| SCHEMBL2014280 | 0.81 | MEN1 (0.52) | ALDH1A1KDM4ETDP1KMT2AMAPT | |
| SCHEMBL2013318 | 0.81 | L3MBTL1 (0.53) | ALDH1A1TSHRKDM4ETDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |