Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20145228 | 0.81 | IL1B (0.54) | CCNKCDK12 | |
| SCHEMBL20145208 | 0.81 | CCR6 (0.51) | CCNKCDK12DPP4HCRTR1HCRTR2 | |
| SCHEMBL28545513 | 0.75 | MAPK1 (0.49) | CCNKCDK12 | |
| SCHEMBL28545510 | 0.75 | MAPK1 (0.49) | CCNKCDK12 | |
| SCHEMBL28552999 | 0.75 | CCNK (0.60) | CCNKCDK12LMNAGAAHCAR3 | |
| SCHEMBL28552998 | 0.75 | CCNK (0.60) | CCNKCDK12LMNAGAAHCAR3 | |
| SCHEMBL15739537 | 0.75 | HCAR3 (0.56) | CCNKCDK12TSHRHCAR3L3MBTL1 | |
| SCHEMBL23073961 | 0.74 | HSD11B1 (0.39) | DPP4LMNAGAATSHR | |
| SCHEMBL13592662 | 0.74 | HSD11B1 (0.39) | DPP4LMNAGAATSHR | |
| Hydrochloric Acid SCHEMBL28911922 | 0.74 | MAPK1 (0.48) | CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |