SCHEMBL2014794

SCHEMBL2014794

CC(C)COC(=O)COc1ccc(C(=O)CNC(=O)OC(C)(C)C)cc1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.40
MAPT P10636 2/20 0.40
HPGD P15428 1/20 0.40
CA12 O43570 5/20 0.39
CA1 P00915 5/20 0.39
CA2 P00918 5/20 0.39
CA9 Q16790 5/20 0.39
TSHR P16473 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
HRH2 P25021 3/20 0.37
HRH1 P35367 3/20 0.37
EPHX2 P34913 1/20 0.37
NR1H4 Q96RI1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2013987 0.86 MAPT (0.49) MAPTHPGDCA12CA1CA2
SCHEMBL2014829 0.86 L3MBTL1 (0.44) L3MBTL1TSHRTDP1EPHX2
SCHEMBL8377749 0.84 CA12 (0.44) L3MBTL1MAPTHPGDCA12CA1
SCHEMBL2009205 0.83 SMN1; SMN2 (0.51) MAPTCA12CA1CA2CA9
SCHEMBL2013045 0.82 SMN1; SMN2 (0.49) L3MBTL1MAPT
SCHEMBL5782184 0.82 RAB9A (0.39) MAPTHPGDHRH2HRH1
SCHEMBL12413739 0.77 MEN1 (0.44) MAPTHPGDCA12CA1CA2
SCHEMBL3604860 0.77 RAB9A (0.49) MAPTCA12CA1CA2CA9
Methenamine SCHEMBL5801339 0.77 EPHX2 (0.48) MAPTCA12CA1CA2CA9
SCHEMBL2007499 0.76 L3MBTL1 (0.46) L3MBTL1MAPTHPGDTSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7964628-B2 Fibrinogen receptor antagonists and their use PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-06-21 US disclosed
US-20100256161-A1 FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE PIRAMAL LIFE SCIENCES LIMITED (IN) 2010-10-07 US disclosed
US-7759387-B2 Fibrinogen receptor antagonists and their use PIRAMAL LIFE SCIENCES LIMITED (IN) 2010-07-20 US disclosed
US-20070021489-A1 Fibrinogen receptor antagonists and their use NICHOLAS PIRAMAL INDIA LIMITED (IN) 2007-01-25 US disclosed
EP-1677783-A2 FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE Nicholas Piramal India Limited (IN) 2006-07-12 EP disclosed
WO-2005035495-A2 FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE NICHOLAS PIRAMAL INDIA LIMITED (IN) 2005-04-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256161-A1 FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE FGB, F13B, F2 L3MBTL1 4640/4885MAPT 4727/4885HPGD 1551/4885
US-20070021489-A1 Fibrinogen receptor antagonists and their use FGB, F13B, F2 L3MBTL1 4640/4885MAPT 4727/4885HPGD 1551/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.