Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PAM | P19021 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014494 | 1.00 | DGKA (0.47) | DGKACYP1A2ALDH1A1TDP1TSHR | |
| SCHEMBL2011975 | 1.00 | DGKA (0.47) | DGKACYP1A2ALDH1A1TDP1TSHR | |
| SCHEMBL2012551 | 1.00 | DGKA (0.47) | DGKACYP1A2ALDH1A1TDP1TSHR | |
| SCHEMBL2012721 | 1.00 | DGKA (0.47) | DGKACYP1A2ALDH1A1TDP1TSHR | |
| SCHEMBL2015422 | 1.00 | DGKA (0.47) | DGKACYP1A2ALDH1A1TDP1TSHR | |
| SCHEMBL2012707 | 0.98 | CYP1A2 (0.48) | DGKACYP1A2ALDH1A1TDP1TSHR | |
| SCHEMBL2010912 | 0.93 | CYP1A2 (0.50) | DGKACYP1A2ALDH1A1TDP1TSHR | |
| SCHEMBL2011000 | 0.85 | CYP1A2 (0.44) | DGKACYP1A2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL10063280 | 0.84 | CA12 (0.44) | DGKAALDH1A1TDP1DNM1 | |
| SCHEMBL22615113 | 0.83 | DGKA (0.62) | DGKAALDH1A1TDP1TSHRDNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2911656-B1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SA (FR) | 2020-12-02 | — | — | EP | disclosed |
| US-9446015-B2 | Quinone based nitric oxide donating compounds for ophthalmic use | NICOX SCIENCE IRELAND (IE) | 2016-09-20 | — | — | US | disclosed |
| US-9365489-B2 | Nitrooxy alkanoic acids and derivatives thereof in feed for reducing methane emission in ruminants, and/or to improve ruminant performance | DSM IP ASSETS B.V. (NL) | 2016-06-14 | — | — | US | disclosed |
| US-20150283106-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SA (FR) | 2015-10-08 | — | — | US | disclosed |
| EP-2911656-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | Nicox Science Ireland (IE) | 2015-09-02 | — | — | EP | disclosed |
| US-9079821-B2 | Quinone based nitric oxide donating compounds | NICOX SCIENCE IRELAND (IE) | 2015-07-14 | — | — | US | disclosed |
| US-9061962-B2 | Quinone based nitric oxide donating compounds | NICOX SCIENCE IRELAND (IE) | 2015-06-23 | — | — | US | disclosed |
| EP-2707354-B1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX SCIENCE IRELAND (IE) | 2015-04-29 | — | — | EP | disclosed |
| US-20140342998-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX S.A. (FR) | 2014-11-20 | — | — | US | disclosed |
| US-8784871-B2 | Nitrooxy alkanoic acids and derivatives thereof in feed for reducing methane emission in ruminants, and/or to improve ruminant performance | DSM IP ASSETS B.V. (NL) | 2014-07-22 | — | — | US | disclosed |
| US-20140134282-A1 | NITROOXY ALKANOIC ACIDS AND DERIVATIVES THEREOF IN FEED FOR REDUCING METHANE EMISSION IN RUMINANTS, AND/OR TO IMPROVE RUMINANT PERFORMANCE | DSM IP ASSETS B.V. (NL) | 2014-05-15 | — | — | US | disclosed |
| US-20140135389-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX SA (FR) | 2014-05-15 | — | — | US | disclosed |
| WO-2014063923-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX S.A. (FR) | 2014-05-01 | — | — | WO | disclosed |
| EP-2722326-A1 | Quinone based nitric oxide donating compounds | NICOX S.A. (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2707354-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | Nicox S.A. (FR) | 2014-03-19 | — | — | EP | disclosed |
| EP-2509435-B1 | NITROOXY ALKANOIC ACIDS AND DERIVATIVES THEREOF IN FEED FOR REDUCING METHANE EMISSION IN RUMINANTS, AND/OR TO IMPROVE RUMINANT PERFORMANCE | DSM IP ASSETS BV (NL) | 2014-02-26 | — | — | EP | disclosed |
| WO-2013060673-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX S.A. (FR) | 2013-05-02 | — | — | WO | disclosed |
| US-20120315339-A1 | NITROOXY ALKANOIC ACIDS AND DERIVATIVES THEREOF IN FEED FOR REDUCING METHANE EMISSION IN RUMINANTS, AND/OR TO IMPROVE RUMINANT PERFORMANCE | DSM IP ASSETS B.V. (NL) | 2012-12-13 | — | — | US | disclosed |
| EP-2509435-A1 | NITROOXY ALKANOIC ACIDS AND DERIVATIVES THEREOF IN FEED FOR REDUCING METHANE EMISSION IN RUMINANTS, AND/OR TO IMPROVE RUMINANT PERFORMANCE | DSM IP Assets B.V. (NL) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011070133-A1 | NITROOXY ALKANOIC ACIDS AND DERIVATIVES THEREOF IN FEED FOR REDUCING METHANE EMISSION IN RUMINANTS, AND/OR TO IMPROVE RUMINANT PERFORMANCE | DSM IP ASSETS B.V. (NL) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140134282-A1 | NITROOXY ALKANOIC ACIDS AND DERIVATIVES THEREOF IN FEED FOR REDUCING METHANE EMISSION IN RUMINANTS, AND/OR TO IMPROVE RUMINANT PERFORMANCE | PIGS, TECR, CYP4X1 | DGKA 3780/4885CYP1A2 147/4885ALDH1A1 2126/4885 |
| US-20120315339-A1 | NITROOXY ALKANOIC ACIDS AND DERIVATIVES THEREOF IN FEED FOR REDUCING METHANE EMISSION IN RUMINANTS, AND/OR TO IMPROVE RUMINANT PERFORMANCE | PIGS, TECR, CYP4X1 | DGKA 3780/4885CYP1A2 147/4885ALDH1A1 2126/4885 |
| US-20150283106-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NOS1, NOS3, NOS2 | DGKA 1313/4885CYP1A2 346/4885ALDH1A1 265/4885 |
| US-20140135389-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NOS2, NQO1, NOS1 | DGKA 2299/4885CYP1A2 321/4885ALDH1A1 339/4885 |
| US-20140342998-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NOS2, NQO1, NOS1 | DGKA 2299/4885CYP1A2 321/4885ALDH1A1 339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.