Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 11/20 | 0.45 |
| ▸ | MLYCD | O95822 | 4/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | RORA | P35398 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20149089 | 0.81 | NR1H2 (0.43) | NR1H2NR1H3MLYCDHSD11B1NR1I2 | |
| SCHEMBL8021367 | 0.78 | NR1H2 (0.58) | NR1H2NR1H3MLYCDNR1I2RORC | |
| SCHEMBL18745627 | 0.75 | NFE2L2 (0.44) | LMNAHTTNPSR1SMN1; SMN2 | |
| SCHEMBL13324724 | 0.75 | NR1H2 (0.56) | NR1H2NR1H3MLYCDLMNAHTT | |
| SCHEMBL16847361 | 0.73 | HSD11B1 (0.38) | HSD11B1HTT | |
| SCHEMBL8053971 | 0.73 | HSD11B1 (0.38) | HSD11B1HTT | |
| SCHEMBL17086713 | 0.73 | HSD11B1 (0.38) | HSD11B1HTT | |
| SCHEMBL6337812 | 0.72 | NR1H2 (0.53) | NR1H2NR1H3MLYCDLMNAHTT | |
| SCHEMBL18698639 | 0.72 | NR1H2 (0.53) | NR1H2NR1H3MLYCDLMNAHTT | |
| Water SCHEMBL1684070 | 0.72 | NR1H2 (0.65) | NR1H2NR1H3MLYCDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |