Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDH1 | P12830 | 1/20 | 1.00 |
| ▸ | CTNNB1 | P35222 | 1/20 | 1.00 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL892967 | 0.91 | CDH1 (0.82) | CDH1CTNNB1TCF7L2ALDH1A1HPGD | |
| SCHEMBL18257901 | 0.82 | CDH1 (0.70) | CDH1CTNNB1TCF7L2ALDH1A1HPGD | |
| SCHEMBL892240 | 0.80 | HPGD (1.00) | CDH1CTNNB1TCF7L2ALDH1A1HPGD | |
| SCHEMBL16401825 | 0.78 | CDH1 (0.63) | CDH1CTNNB1TCF7L2ALDH1A1MAPT | |
| SCHEMBL11902926 | 0.77 | ALDH1A1 (0.67) | CDH1CTNNB1TCF7L2ALDH1A1HPGD | |
| SCHEMBL11275129 | 0.76 | CDH1 (0.61) | CDH1CTNNB1TCF7L2ALDH1A1MAPT | |
| SCHEMBL72786 | 0.76 | ALDH1A1 (1.00) | CDH1CTNNB1TCF7L2ALDH1A1HPGD | |
| SCHEMBL71299 | 0.76 | ALDH1A1 (1.00) | CDH1CTNNB1TCF7L2ALDH1A1HPGD | |
| SCHEMBL11902059 | 0.75 | CDH1 (0.59) | CDH1CTNNB1TCF7L2ALDH1A1HPGD | |
| SCHEMBL1178695 | 0.74 | ALDH1A1 (0.72) | CDH1CTNNB1TCF7L2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273246-B2 | Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3′,4′:5,6] pyrazino[2,3-B] indole analogs as inhibitors of β-catenin/T-cell factor protein-protein interactions | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2019-04-30 | — | — | US | disclosed |
| US-20180134729-A1 | METHODS AND COMPOSITIONS OF SUBSTITUTED 5H-[1,2,5] OXADIAZOLO [3',4':5,6] PYRAZINO[2,3-B] INDOLE ANALOGS AS INHIBITORS OF BETA-CATENIN/T-CELL FACTOR PROTEIN-PROTEIN INTERACTIONS | UNIVERSITY OF UTAH | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134729-A1 | METHODS AND COMPOSITIONS OF SUBSTITUTED 5H-[1,2,5] OXADIAZOLO [3',4':5,6] PYRAZINO[2,3-B] INDOLE ANALOGS AS INHIBITORS OF BETA-CATENIN/T-CELL FACTOR PROTEIN-PROTEIN INTERACTIONS | CTNNB1, CTNNBL1, WNT3A | CDH1 2090/4885CTNNB1 1/4885TCF7L2 31/4885 |
| US-10273246-B2 | Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3′,4′:5,6] pyrazino[2,3-B] indole analogs as inhibitors of β-catenin/T-cell factor protein-protein interactions | CTNNB1, CTNNBL1, WNT3A | CDH1 2064/4885CTNNB1 1/4885TCF7L2 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.