Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 11/20 | 0.33 |
| ▸ | ITGAV | P06756 | 10/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24521880 | 0.86 | SUCNR1 (0.38) | ITGB3ITGAV | |
| SCHEMBL24521878 | 0.81 | ITGAV (0.57) | ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL24521828 | 0.81 | ITGAV (0.60) | ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL20153459 | 0.78 | KCNK3 (0.34) | ITGB3ITGAVKCNK3KCNK9ITGA2B | |
| SCHEMBL20153460 | 0.76 | SUCNR1 (0.39) | ITGB3ITGAV | |
| SCHEMBL20153379 | 0.76 | ITGB3 (0.33) | ITGB3ITGAVKCNK3TRPM8 | |
| SCHEMBL17262997 | 0.72 | ADRB3 (0.38) | ITGB3ITGAVKCNK3KCNK9NR3C1 | |
| SCHEMBL13719466 | 0.72 | ADRB3 (0.38) | ITGB3ITGAVKCNK3KCNK9NR3C1 | |
| SCHEMBL20153461 | 0.72 | ITGAV (0.59) | ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL20087016 | 0.72 | ADRB3 (0.38) | ITGB3ITGAVKCNK3KCNK9NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538525-B1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-22 | — | — | EP | disclosed |
| WO-2018089353-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |