Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983581 | 0.89 | ALDH1A1 (0.54) | GAAKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL4514894 | 0.89 | ALDH1A1 (0.54) | GAAKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL12939708 | 0.85 | GAA (0.69) | GAAKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL12793343 | 0.84 | USP2 (0.71) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL1020620 | 0.83 | KMT2A (0.66) | GAAMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL5249802 | 0.82 | LMNA (0.71) | KDM4EMEN1KMT2AALDH1A1PKM | |
| SCHEMBL4940237 | 0.82 | ALDH1A1 (0.64) | GAAKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL29764451 | 0.82 | HSD11B1 (0.58) | GAAMEN1KMT2AALDH1A1HSD11B1 | |
| SCHEMBL15800491 | 0.82 | HSD11B1 (0.58) | MEN1KMT2ANPC1ALDH1A1PKM | |
| SCHEMBL1019079 | 0.82 | MEN1 (0.60) | MEN1KMT2AALDH1A1PKMHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117447385-A | Preparation and application of deuterated 3-aminomethyl-4-phenylpiperidin-4-ol compound | 南昌双天使生物科技开发有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-102617451-B | Pipradrol derivatives with pesticidal activity as well as preparation and application thereof | UNIV EAST CHINA SCIENCE & TECH | 2014-01-22 | — | — | CN | disclosed |
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| CN-102617451-A | Pipradrol derivatives with pesticidal activity as well as preparation and application thereof | UNIV EAST CHINA SCIENCE & TECH | 2012-08-01 | — | — | CN | disclosed |
| WO-2011075517-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| WO-2009133127-A1 | FUSED BICYCLIC COMPOUNDS AND USE THEREOF AS PI3K INHIBITORS | MERCK SERONO S.A. (CH) | 2009-11-05 | — | — | WO | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | GAA 2353/4885KDM4E 1296/4885MEN1 1354/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | GAA 2688/4885KDM4E 1360/4885MEN1 1687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.