Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.40 |
| ▸ | ITGAV | P06756 | 16/20 | 0.40 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 6/20 | 0.37 |
| ▸ | ITGB8 | P26012 | 5/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156349 | 0.87 | ITGB3 (0.49) | ITGB3ITGAVITGB6ITGA2BITGB5 | |
| SCHEMBL20156078 | 0.85 | RXFP1 (0.35) | PDE2AMEN1ALDH1A1KMT2A | |
| SCHEMBL20156283 | 0.84 | ITGB3 (0.38) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL20156301 | 0.80 | ITGB3 (0.57) | ITGB3ITGAVITGB6ITGA2BITGB5 | |
| SCHEMBL23912904 | 0.78 | ITGAV (0.39) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL21281625 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGB6ITGA2BITGB5 | |
| SCHEMBL23912908 | 0.77 | NPC1 (0.34) | ITGB3ITGAVPDE2AMAPK1MEN1 | |
| SCHEMBL23912902 | 0.73 | ITGB3 (0.53) | ITGB3ITGAVITGB6ITGA2BITGB5 | |
| SCHEMBL23912864 | 0.71 | ITGB3 (0.60) | ITGB3ITGAVITGB6ITGA2BITGB5 | |
| SCHEMBL20156082 | 0.71 | ITGB3 (0.49) | ITGB3ITGAVITGB6ITGA2BITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538527-B1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2018089358-A1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |