Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.30 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156962 | 0.77 | TRPV4 (0.44) | TRPV4ADRB2ADRB1BACE2KHK | |
| SCHEMBL3628472 | 0.72 | TRPV4 (0.50) | TRPV4ADRB2ADRB1BACE2KHK | |
| SCHEMBL3186092 | 0.72 | TRPV4 (0.50) | TRPV4ADRB2ADRB1BACE2KHK | |
| SCHEMBL14566112 | 0.70 | PKM (0.42) | — | |
| SCHEMBL6651303 | 0.69 | TRPV4 (0.71) | TRPV4KHKCYP11B1CYP11B2 | |
| SCHEMBL4624565 | 0.66 | TRPV4 (0.43) | TRPV4USP30 | |
| SCHEMBL2081398 | 0.65 | TRPV4 (0.45) | TRPV4ADRB2ADRB1BACE2KHK | |
| SCHEMBL12413852 | 0.65 | TRPV4 (0.50) | TRPV4ADRB2ADRB1KHKCYP11B1 | |
| SCHEMBL366972 | 0.64 | TRPV4 (0.65) | TRPV4KHKCYP11B1CYP11B2 | |
| SCHEMBL26106182 | 0.64 | ACLY (0.36) | TRPV4ADRB2ADRB1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |