Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | STS | P08842 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11696345 | 0.74 | LMNA (0.47) | HSD17B3HTR7ESR1ESR2ALDH1A1 | |
| SCHEMBL10270183 | 0.73 | TSHR (0.44) | ALDH1A1HSD17B10MAPTKDM4ECYP1A2 | |
| SCHEMBL24633879 | 0.73 | PDE4A (0.37) | HSD17B3ESR1ESR2ALDH1A1HSD17B10 | |
| SCHEMBL23865855 | 0.72 | KDM4E (0.39) | HTR7ALDH1A1HSD17B10THRBMAPT | |
| SCHEMBL5496843 | 0.72 | ERAP2 (0.49) | ALDH1A1HSD17B10HDAC1MAPTKDM4E | |
| SCHEMBL28930606 | 0.70 | HSD17B3 (0.37) | HSD17B3HTR7ESR1ESR2ALDH1A1 | |
| SCHEMBL2017777 | 0.70 | TSHR (0.49) | ALDH1A1HDAC1HDAC8TSHRSLC6A2 | |
| SCHEMBL20686672 | 0.69 | ESR1 (0.49) | HSD17B3ESR1ESR2ALDH1A1CYP1A2 | |
| SCHEMBL7193415 | 0.69 | ALDH1A1 (0.44) | HSD17B3HTR7ESR1ESR2ALDH1A1 | |
| SCHEMBL7187984 | 0.69 | HSD17B3 (0.60) | HSD17B3ESR1ESR2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |