Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157580 | 0.86 | LMNA (0.37) | LMNARAB9ASMN1; SMN2CES2CES1 | |
| SCHEMBL21362731 | 0.86 | NPC1 (0.38) | LMNANPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL20157553 | 0.85 | POLB (0.36) | LMNASMN1; SMN2CES2CES1THRB | |
| SCHEMBL20157516 | 0.84 | ALDH1A1 (0.48) | LMNARAB9ASMN1; SMN2CES2CES1 | |
| SCHEMBL20158008 | 0.83 | HPGD (0.40) | LMNANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL20157560 | 0.82 | PTPN1 (0.43) | LMNANPC1SMN1; SMN2CES2CES1 | |
| SCHEMBL8005599 | 0.80 | LMNA (0.67) | LMNANPC1RAB9ASMN1; SMN2CES2 | |
| SCHEMBL20157523 | 0.80 | CES2 (0.39) | LMNANPC1SMN1; SMN2CES2CES1 | |
| SCHEMBL21362538 | 0.80 | SRD5A2 (0.39) | LMNANPC1RAB9ASMN1; SMN2CES2 | |
| SCHEMBL20157557 | 0.80 | PTPN1 (0.39) | LMNACES2CES1THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018086605-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |