Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147578 | 0.91 | MT-CO2 (0.46) | TAS1R3TAS1R1TAS1R2P2RX7RET | |
| SCHEMBL20147943 | 0.82 | TAS1R3 (0.41) | TAS1R3TAS1R1TAS1R2RETMT-CO2 | |
| SCHEMBL20205892 | 0.81 | MT-CO2 (0.46) | TAS1R3TAS1R1TAS1R2P2RX7RET | |
| SCHEMBL20147551 | 0.79 | P2RX7 (0.47) | P2RX7MT-CO2F9 | |
| SCHEMBL20206058 | 0.78 | BCAT2 (0.45) | P2RX7RET | |
| SCHEMBL20158552 | 0.77 | RET (0.42) | P2RX7RET | |
| SCHEMBL20147562 | 0.76 | RET (0.41) | TAS1R3TAS1R1TAS1R2P2RX7RET | |
| SCHEMBL20069745 | 0.75 | P2RX7 (0.46) | P2RX7F9 | |
| SCHEMBL20147570 | 0.74 | HCN1 (0.47) | P2RX7RET | |
| SCHEMBL20069756 | 0.74 | P2RX7 (0.47) | P2RX7RETCCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10172845-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180134703-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10172845-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | TAS1R3 1218/4885TAS1R1 1405/4885TAS1R2 2051/4885 |
| US-20180134703-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | TAS1R3 1218/4885TAS1R1 1405/4885TAS1R2 2051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.