Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 5/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159115 | 0.85 | MTOR (0.55) | PTGS1PTGS2HRH3 | |
| SCHEMBL20159010 | 0.81 | PTGS1 (0.45) | PTGS1PTGS2TP53KDM4E | |
| SCHEMBL20159008 | 0.81 | NPY2R (0.51) | PTGS1PTGS2HRH3 | |
| SCHEMBL20159066 | 0.79 | MTOR (0.45) | PTGS1PTGS2HRH3 | |
| SCHEMBL20159024 | 0.78 | MTOR (0.64) | KMT2AHRH3 | |
| SCHEMBL20159009 | 0.77 | PTGS1 (0.46) | PTGS1PTGS2TP53HRH3 | |
| SCHEMBL20159286 | 0.77 | MTOR (0.51) | HRH3 | |
| SCHEMBL20159079 | 0.76 | MTOR (0.52) | CHRM4HRH3 | |
| SCHEMBL20159109 | 0.73 | MTOR (0.50) | CHRM4PTGS1PTGS2TP53 | |
| SCHEMBL20139225 | 0.73 | MTOR (0.50) | CHRM4KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |