Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159115 | 0.84 | MTOR (0.55) | PTGS1PTGS2POLBMTORRPTOR | |
| SCHEMBL20159006 | 0.81 | CHRM4 (0.47) | PTGS1PTGS2TP53KDM4E | |
| SCHEMBL20159066 | 0.78 | MTOR (0.45) | PTGS1PTGS2POLBMTORRPTOR | |
| SCHEMBL20159024 | 0.76 | MTOR (0.64) | POLBMTORRPTORMLST8 | |
| SCHEMBL20159009 | 0.76 | PTGS1 (0.46) | PTGS1PTGS2POLBMTORRPTOR | |
| SCHEMBL20159008 | 0.76 | NPY2R (0.51) | PTGS1PTGS2POLBMTORRPTOR | |
| SCHEMBL20159286 | 0.76 | MTOR (0.51) | POLBMTORRPTORMLST8LMNA | |
| SCHEMBL20159079 | 0.74 | MTOR (0.52) | POLBMTORRPTORMLST8LMNA | |
| SCHEMBL20159109 | 0.72 | MTOR (0.50) | PTGS1PTGS2MTORRPTORMLST8 | |
| SCHEMBL20140500 | 0.71 | MTOR (0.67) | PTGS1PTGS2MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |