Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159040 | 0.82 | MTOR (0.52) | DRD2CHRM4LMNATP53MAPT | |
| SCHEMBL20139783 | 0.78 | SCD5 (0.44) | CHRM4NPC1RAB9AMAPTCTSB | |
| SCHEMBL20139784 | 0.78 | SCD5 (0.44) | CHRM4NPC1RAB9AMAPTCTSB | |
| SCHEMBL20140557 | 0.78 | SCD5 (0.44) | CHRM4NPC1RAB9AMAPTCTSB | |
| SCHEMBL20156992 | 0.70 | GRM1 (0.40) | DRD2CHRM4CHRM2KMT2A | |
| SCHEMBL20140102 | 0.70 | GRM1 (0.40) | DRD2CHRM4CHRM2KMT2A | |
| SCHEMBL20139330 | 0.69 | FAAH (0.44) | CHRM4NPC1RAB9ALMNATP53 | |
| SCHEMBL20139331 | 0.69 | FAAH (0.44) | CHRM4NPC1RAB9ALMNATP53 | |
| SCHEMBL20139199 | 0.68 | FAAH (0.56) | — | |
| SCHEMBL15819221 | 0.68 | FAAH (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |