Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | USP8 | P40818 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL573864 | 0.78 | MAOB (0.53) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL21131569 | 0.76 | TRPV4 (0.45) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL57346 | 0.76 | TRPV4 (0.61) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL30919072 | 0.76 | TRPV4 (0.61) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| Ethylene SCHEMBL27960950 | 0.74 | MAOB (0.50) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL17796265 | 0.73 | TRPV4 (0.42) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL21872468 | 0.73 | AR (0.42) | TRPV4CYP11B2CYP11B1ARKMT2A | |
| SCHEMBL8119607 | 0.73 | TRPV4 (0.42) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL52204 | 0.73 | TRPV4 (0.47) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL404482 | 0.73 | ALDH1A1 (0.44) | TRPV4MAOAMAOBCYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |