Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.53 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21569629 | 0.85 | DNM1 (0.41) | KEAP1NFE2L2DNM1SIGMAR1LMNA | |
| SCHEMBL15721226 | 0.83 | KEAP1 (0.52) | KEAP1NFE2L2SIGMAR1PARP1DRD2 | |
| SCHEMBL9478831 | 0.79 | LMNA (0.48) | LMNA | |
| SCHEMBL13817642 | 0.79 | LMNA (0.53) | LMNA | |
| SCHEMBL24352361 | 0.77 | KEAP1 (0.50) | KEAP1NFE2L2SIGMAR1KDM4EPARP1 | |
| SCHEMBL10274873 | 0.76 | KEAP1 (0.48) | KEAP1NFE2L2SIGMAR1PARP1PIK3CA | |
| SCHEMBL19098397 | 0.75 | GNAI3 (0.39) | LMNAKDM4EPAOX | |
| SCHEMBL20159513 | 0.75 | GNAI3 (0.49) | LMNA | |
| SCHEMBL27259890 | 0.75 | KEAP1 (0.48) | KEAP1NFE2L2SIGMAR1KDM4EPARP1 | |
| SCHEMBL12906768 | 0.75 | KEAP1 (0.48) | KEAP1NFE2L2SIGMAR1KDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089695-A1 | TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |